A recent study has found that loneliness and social isolation may have direct biological effects that contribute to serious health problems, including cardiovascular disease and premature death.
Researchers analysed data from over 40,000 participants in the UK Biobank, identifying key proteins associated with these social conditions. “We’ve never understood why loneliness affects health, but our work has uncovered proteins that appear to play a crucial role,” said Dr. Chun Shen, lead author from the University of Cambridge.
The study found that loneliness and isolation are linked to various proteins involved in inflammation and immune responses, which may drive conditions like stroke, type 2 diabetes, and mortality.
“Social isolation is a growing global issue, and the World Health Organisation has recognised it as a public health concern,” added Dr. Barbara Sahakian, corresponding author. The research highlights that these biological markers could lead to new strategies for prevention and treatment.
Experts agree that understanding the biological processes at play could open new avenues for intervention. “This could allow doctors to target prevention more effectively,” said Dr. Dilip V. Jeste, a mental health expert.
Sahakian further suggested practical approaches, such as “social prescribing,” where doctors encourage patients to engage in community activities to combat loneliness. This study emphasises the need for greater attention to social health and its far-reaching impacts
